Chang

Liu ZC & Chang TMS, Artificial Cell microencapsulated stem cells in regenerative medicine, tissue engineering and cell therapy Advances in Experimental Medicine and Biology. 670: 68-79 (2010)

Zhu HG, Du QQ, Chen C and Chang TMS, The immunological properties of polyhemoglobin containing catalase and superoxide dismutase activities prepared by polymerized bovine stroma-free hemoglobin. Artificial Cells, Blood Substitutes & Biotechnology 38: 57-64 (2010)

Chang TMS, Blood replacement with engineered hemoglobin and hemoglobin nanocapsules. Wiley Interdisciplinary Reviews on Nanomedicine and Nanobiotechnology (advance review) 2: 418-43 (2010)

Chang TMS, Artificial Cells containing Stem Cells for Liver Failure. Feature article in Special Issue on Stem Cells, Asia Pacific Biotechnology (APBN) 14: (3), 17-19 (2010)

Collins

Manj贸n Herrera JV, Coup茅 P, Bonmati LM, Collins DL, and Robles M, "Adaptive Non-Local Means Denoising of MR Images with Spatially Varying Noise Levels," J Mag Res Imag., Vol. 31, Issue 1, 192-203, 2010

Caramanos Z, Fonov V, Francis SJ, Narayanan S, Pike GB, Collins DL, and Arnold DL, "Gradient Distortions in MRI: Characterizing and Correcting For Their Effects on SIENA-Generated Measures of Brain Volume Change," NeuroImage, 49(2), 1601-1611. (Corrigendum: NeuroImage, 49, 3498), February 2010.

Hellier P, Coup茅 P, Morandi X and Collins DL, "An automatic geometrical and statistical method to detect acoustic shadows in intraoperative ultrasound brain images", Medical Image Analysis, 14(2) 195-204, February 2010.

Toews M,Wells III W, Collins DL, Arbel, T "Feature-Based Morphometry: Discovering Group-related Anatomical Patterns," NeuroImage, 49(3) 2318-2327, February 2010.

Tardif C, Collins DL and Pike GB, "Regional impact of field strength on voxel-based morphometry results", Human Brain Mapping, HBM-09-0187.R2, 31:943-957, July 2010.

Coup茅 P, Manjon JV, Gedamu E, Arnold DL, Robles M, and Collins DL, "Robust Rician Noise Estimation for MR Images", Medical Image Analysis 14 (2010) 483-493.

Derakhshan M, Caramanos Z, Giacomini PS, Narayanan S, Maranzano J, Francis SJ, Arnold DL and Collins DL, "Evaluation of Automated Techniques for the Quantification of Grey Matter Atrophy in Patients with Multiple Sclerosis," NeuroImage, Vol.52, 1261-1267, July 2010.

Kish SJ, Lerch J, Furukawa Y, Tong J, McCluskey T, Wilkins D, Houle S, Meyer J, Mundo E, Wilson AA, Rusjan PM, Saint-Cyr J, Guttman M, Collins DL, Shapiro C, Warsh JJ and Boileau I, "Decreased Cerebral Cortical Serotonin Transporter Binding in Ecstasy Users: A PET[11C]DASB and Structural Brain Imaging Study", Brain, 2010, 133, 1779-1797.

Manj贸n JV, Coup茅 P, Buades A, Fonov V, Collins DL and Robles M, "Non-Local MRI Upsampling", Medical Image Analysis, e-pub June 4, 2010.

Coup茅 P, Manjon J, Fonov V, Pruessner J, Robles M and Collins DL, "Nonlocal Patch-based label fusion for Hippocampus Segmentation," #615. MICCAI 2010, 13th International Conference on Medical Image Computing and Computer Assisted Intervention, Beijing, China, September 20-24, 2010.

Chen SJ, Hellier P, Gauvrit J-Y, Marchal M, Morandi X and Collins DL, "An anthropomorphic polyvinyl alcohol triple modality brain phantom based on Colin27," #314. MICCAI 2010, 13th International Conference on Medical Image Computing and Computer Assisted Intervention, Beijing, China, September 20-24, 2010.

Tardif CL, Collins DL, Eskildsen, SF, Richardson JB and Pike GB, "Segmentation of Cortical Multiple Sclerosis Lesions on MRI using Automated Laminar Profile Shape Analysis," #896. MICCAI 2010, 13th International Conference on Medical Image Computing and Computer Assisted Intervention, Beijing, China, September 20-24, 2010.

Elliott C, Francis S, Arnold DL, Collins DL and Arbel T, "Bayesian classification of Multiple Sclerosis lesions in longitudinal MRI using subtraction images," #1026. MICCAI 2010, 13th International Conference on Medical Image Computing and Computer Assisted Intervention, Beijing, China, September 20-24, 2010.

DeNigris D, Mercier L, Del Maestro R, Collins DL and Arbel T, "Hierarchical Multimodal Image Registration Based on Adaptive Local Mutual Information," #1197. MICCAI 2010, 13th International Conference on Medical Image Computing and Computer Assisted Intervention, Beijing, China, September 20-24, 2010.

Fonov V, Janke A, Caramanos Z, Arnold DL, Narayanan S, Pike GB and Collins DL, "Improved precision in the measurement of longitudinal global and regional volumetric changes via a novel MRI gradient distortion characterization and correction technique," MIAR 2010, 5th International Workshop on Medical Imaging and Augmented Reality, September 19-20, 2010, Beijing, China. Lecture Notes in Computer Science 6326, 324-333, 2010, Springer.

Guizard N, Coupe P, Stifani N, Stifani S and Collins DL, "Robust 3D Reconstruction and Mean-Shift Clustering of Motoneurons from Serial Histological Images," MIAR 2010, 5th International Workshop on Medical Imaging and Augmented Reality, September 19-20, 2010, Beijing, China. Lecture Notes in Computer Science, Springer.

Guizard N, Fonov V, Aubert-Broche B and Collins DL, "Impact of Non-Linear Registration Symmetry in Longitudinal MRI Studies", submitted to Spatio Temporal Image Analyses (STIA), Medical Image Computing and Computer Assisted Intervention Conference (MICCAI) 2010, September 2010, Beijing.

Rajalingham R, Toews M, Collins DL, Arbel T, "Exploring Cortical Folding Pattern Variability Using Local Image Features", accepted to the Workshop on Medical Computer Vision (MCV) Medical Image Computing and Computer Assisted Intervention 2010 (MICCAI 2010), Beijing, China, September 2010.

Funnell

Munguia R, Sahmkow SI, Daniel SJ & Funnell WRJ, Transtympanic Ringer's lactate application in the prevention of cisplatinum-induced ototoxicity in a chinchilla animal model. Otolaryngol Head & Neck Surg 143(1): 134-140 (2010)

Gea SLR, Decraemer WF, Funnell WRJ, Dirckx JJJ & Maier H, Tympanic-membrane boundary conditions derived from static displacements observed with computerized tomography in human and gerbil. J Assoc Res Otolaryngol 11: 1-17 (2010)

Galiana

Ghoreyshi A and Galiana HL, Simultaneous identification of oculomotor subsystems using hybrid system identification for multi-input single-output systems: Introducing Hybrid extended least squares (HybELS), IEEE Trans. Biomedical Engineering 57: 1089-1098 (2010)

Ghoreyshi A & Galiana HL, GNL-HybELS: An algorithm to classify and identify VOR responses simultaneously, Proc. 32nd Ann. Intern. Conference of the IEEE EMBS, Buenos Aires, Argentina, pp. 2346-9, Sept. 1-4, 2010

Juncker

Li H, Leulmi RF and Juncker D, Hydrogel droplet microarrays with trapped antibody-functionalized beads for multiplexed protein analysis, Lab Chip, advance online publication (2010)

Perrault CM, Qasaimeh MA, Brastaviceanu T, Anderson K, Kabakibo Y and Juncker D, Integrated microfluidic probe station, Review of Scientific Instruments 81 115107, 8 pp. (2010)

Mirzaei M, Pla-Roca M, Safavieh R, Nazarova E, Safavieh M, Li H, Vogel J, and Juncker D, Microfluidic perfusion system for culturing and imaging yeast cells microarrays and rapidly exchanging media Lab Chip 10, 2449 - 2457 (2010)

Bourbeillon J, Orchard S, Benhar I, Borrebaeck C, de Daruvar A, D眉bel S, Frank R, Gibson F, Gloriam D, N. Haslam N, Hiltker T, Humphrey-Smith I, Hust M, Juncker D, Koegl M, Konthur Z, Korn B, Krobitsch S, Muyldermans S, Nygren P-A, Palcy S, Polic B, Rodriguez H, Sawyer A, Schlapshy M, Snyder M, Stoevesandt O, Taussig MJ, Templin M, Uhlen M, van der Maarel S, Wingren C, Hermjakob H, Sherman D, Minimum Information about a Protein Affinity Reagent (MIAPAR) , Nature Biotechnology 28, 650-653 (2010)

Safavieh R, Qasaimeh M, Pla Roca M, Mirzaei M and Juncker D, Straight SU-8 Pins Journal of Micromechanics and Microengineering 20 055001, 9 pp. (2010)

Pekas N, Zhang Q, Nannini M, Juncker D, Wet-etching of structures with straight facets and adjustable taper into glass substrates , Lab on a Chip 10, 494 - 498 (2010)

Queval A, Ghattamaneni N, Perrault C, Mirzaei M, Gill R, McKinney BA, Juncker D, Chamber and Microfluidic Probe for Microperfusion of Organotypic Brain Slices, Lab on a Chip, 10, 326 - 334 (2010)

Safavieh M, Qasaimeh MA, Safavieh R and Juncker D. Characterization of Two Apertures Microfluidic Probe, Proceedings of MicroTAS 2010, The fourteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, Oct 3-7, pp.369-371. 2010.

Zhou Z, Safaviah R, Mao X and Juncker D. Immunoassay on Cotton Yarn for Low-Cost Diagnostics, Proceedings of MicroTAS 2010, The fourteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, Oct 3-7, pp.25-27. 2010.

Li H, Leulmi RF and Juncker D,Beads-in-Gels Antibody Microarrays for Multiplexed Protein Profiling, Proceedings of MicroTAS 2010, The fourteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, Oct 3-7, pp.1451-1453. 2010.

Qasaimeh MA and Juncker D, Floating Microfluidic Gradients Proceedings of MicroTAS 2010, The fourteenth International Conference on Miniaturizes Systems for Chemistry and Life Sciences, Groningen, The Netherlands, Oct 3-7, pp.1844-1846. 2010

Kearney

Carrillo B, Yanofsky C, Laboissiere S, Nadon R and Kearney RE, "Methods for combining peptide intensities to estimate relative protein abundance." Bioinformatics 26: 98-103. (2010).

Warrick PA, Hamilton EF, Precup D, Kearney RE, Classification of Normal And Hypoxic Fetuses from Systems Modelling of Intra-Partum Cardiotocography. IEEE Trans Biomed Eng 57: 771-779 (2010)

Vedula S, Kearney RE, Stapley P, Decoupling of stretch reflex and background muscle activity during anticipatory postural adjustments in humans. Experimental Brain Research, 205: 205-215 (2010)

Roy L, LaBoissiere S, Abdou E, Thibault G, Hamel N, Taheri M, Boismenu D, Lanoix J, Kearney RE, Paiement JM, Proteomic analysis of the transitional endoplasmic reticulum in hepatocellular carcinoma: An organelle perspective on cancer. Biochem Biophys Acta 1804: 1869-1881 (2010)

Zhao Y, Westwick DT and Kearney RE, Subspace Method for Identification of Human Ankle Joint Stiffness. IEEE Trans Biomed Eng, published electronically, 15 Nov. 2010. 10.1109/TBME.2010.2092430 (2010)

Nadeau

Dumas E, Gao C, Suffern D, Bradforth S, Dimitrijevic N, Nadeau J, "Interfacial charge transfer between CdTe quantum dots and Gram negative vs. Gram positive bacteria,", Environmental Science and Technology, 44(4): 1464-70 (2010)

Clarke S, Mielke RE, Neal A, Holden P, and Nadeau JL, "Quantum dots for electron and fluorescence microscopy of bacteria and biofilms,", Microscopy and Microanalysis, 26: 1-13 (2010)

Hollmann A, Tzankov A, Mart铆nez-Marignac VL, Baker K, Grygorczyk C, Grygorcyk R, Foulkes W, Nadeau J, Panasci L, Dirnhofer S, Aloyz R. " Therapeutic implications of Src independent calcium mobilization in diffuse large B-cell lymphoma,", Leukemia Research, 34(5): 585-93 (2010)

Cooper D, Dimitrijevic N, Nadeau J, "Photosensitization of CdSe/ZnS QDs and reliability of assays for reactive oxygen species production,", Nanoscale 2(1): 114 -121 (2010)

Jericho S, Klages P, Nadeau J, Dumas EM, Jericho MH, and Kreuzer HJ, "In-line digital holographic microscopy for terrestrial and exobiological research,", Planetary and Space Science 58(4): 701-705 (2010)

Rogers JD, Perreault N, Neiderberger TD, Lichten C, Whyte LG, Nadeau JL, "A life detection problem in a high Arctic microbial community, Planetary and Space Science 58 (4): 623-630 (2010)

Pike

Lotfipour S, Leonard G, Perron M, Pike GB, Richer L, S茅guin JR, Toro R, Veillette S, Pausova Z., Paus T. Prenatal Exposure to Maternal Cigarette Smoking Interacts with a Polymorphism in the 伪6 Nicotinic Acetylcholine Receptor Gene to Influence Drug Use and Striatum Volume in Adolescence. Molecular Psychiatry, 15(1): 6-8, January 2010 .

Paus T, Nawaz-Khan I, Leonard G, Perron M, Pike GB, Pitiot A, Richer L, Susman E, Veillettte S, Pausova Z. Sexual dimorphism in the adolescent brain: Role of testosterone and androgen receptor in global and local volumes of grey and white matter. Hormones and Behavior, 57(1) 63-75, January 2010

Caramanos Z, Fonov V, Francis SJ, Narayanan S, Pike GB, Collins DL, Arnold DL. Gradient Distortions in MRI: Characterizing and Correcting For Their Effects on SIENA-Generated Measures of Brain Volume Change. NeuroImage, 49(2), 1601-1611, January 15, 2010. (Corrigendum: NeuroImage 49(4), 3498, February 15, 2010.

Levesque I, Giacomini PS, Narayanan S, Ribeiro LT, Sled JG, Arnold DL, Pike GB. Quantitative magnetization transfer and myelin water imaging of the evolution of acute multiple sclerosis lesions. Magnetic Resonance in Medicine, 63(3): 633-640, February 2010.

Deslauriers C, Pike GB, Doyon J, Bell E, Palmour N, Racine E. Perspectives of Canadian Researchers on Ethics Review of Neuroimaging Research. Journal of Empirical Research on Human Research Ethics, 49-66, March 2010.

Tardif CL, Collins DL, Pike GB. Regional impact of field strength on voxel-based morphometry results. Human Brain Mapping, 31: 943-957, July 2010.

Levesque I, Chia CLL, Pike GB. Reproducibility of in vivo magnetic resonance imaging- based measurement of myelin water. Journal of Magnetic Resonance Imaging, 32(1): 60-68, 2010.

Chen JJ, Pike GB. Global Cerebral Oxidative Metabolism during Hypercapnia and Hypocapnia in Humans: Implications for BOLD fMRI. Accepted by the Journal of Cerebral Blood Flow and Metabolism, 30(6): 1094-9, June 2010.

Levesque I, Sled JG, Narayanan S, Giacomini PS, Ribeiro LT, Arnold DL, Pike GB. Reproducibility of quantitative magnetization-transfer imaging parameters from repeated measurements. Magnetic Resonance in Medicine, 64(2): 391-400, July 2010.

Mark CI, Slessarev M, Ito S, Han J, Fisher J and Pike GB. Precise control of end-tidal carbin dioxide and oxygen improves BOLD and ASL cerebrovascular reactivity measures. Magnetic Resonance in Medicine, 64(3): 749-56, September 2010.

Zhang Y, Zhang J, Oishi K, Faria AV, Jiang H, Li X, Akhter K, Rosa-Neto P, Pike GB, Evans A, Toga AW, Woods R, Mazziotta JC, Miller MI, van Zijl PCM, Mori S. Atlas-Guided Tract Reconstruction for Automated and Comprehensive Examination of the White Matter Anatomy. NeuroImage, 52(4): 1289-301, October 1, 2010.

Chen JJ, Pike GB. MRI Measurement of the BOLD-Specific Flow-Volume Relationship during Hypercapnia and Hypocapnia in Humans. Neuroimage, 53(2): 383-91, November 1, 2010

Luck D, Buchy L, Czechowska Y, Bodnar M, Pike GB, Campbell J, Achim A, Malla A, Joober R, Lepage M. Fronto-temporal disconnectivity and clinical short-term in first episode psychosis: a DTI-tractography study. Journal of Psychiatr Res., epub, August 11, 2010.

Mark CI, Fisher JA, Pike GB. Improved fMRI calibration: precisely controlled hyperoxic versus hypercapnic stimuli. NeuroImage, epub September 2010.

Radlinska B, Ghinani S, Leppert I, Pike GB, Thiel A. Diffusion Tensor Imaging, Pyramidal Tract Damage and Outcome in Subcortical Stroke. Neurology, 2010, 75: 1048-1054.

Rittner L, Campbell J, Pike GB, Lotufo R. Segmentation of thalamic Nuclei based on Tensorial Morphological Gradient of Diffusion Tensor Fields. ISBI (International Symposium on Biomedical Imaging) 2010, Rotterdam, Netherlands, April 14-17, 2010.

Tardif CL, Collins DL, Eskildsen SF, Richardson JB, Pike GB. Segmentation of Cortical Multiple Sclerosis Lesions on MRI using Automated Laminar Profile Shape Analysis. MICCAI 2010, 13th International Conference on Medical Image Computing Computer Assisted Intervention, Beijing, China, September 20-24, 2010

Fonov VS, Janke A, Caramanos Z, Arnold DL, Narayanan S, Pike GB, Collins DL. Improved precision in the measurement of longitudinal global and regional volumetric changes via a novel MRI gradient distortion characterization and correction technique. MIAR, 5th International Workshop on Medical Imaging and Augmented Reality, Beijing, China, September 19-20, 2010, Lecture Notes in Computer Science 6326, pp. 324-333, 2010.

Prakash

Paul A, Shum-Tim D, Prakash S, BacMam virus transduced cardiomyoblasts can be used for myocardial transplantation using AP-PEG-A microcapsules: molecular cloning, preparation and in vitro analysis. Journal of Biomedicine and Biotechnology Vol. 2010, 1-12, Article ID 858094. (2010)

Paul A, Abbasi S, Shum-Tim D, Prakash S, Nano- and Biotechnological Approaches in Current and Future Generation of Cardiovascular Stents. Current Nanoscience. Vol. 6(5): 469-478. (2010)

Paul A, Shum-Tim D and Prakash S, Investigation on PEG Integrated Alginate-Chitosan Microcapsules for Myocardial Therapy Using Marrow Stem Cells Genetically Modified by Recombinant Baculovirus (2010). Cardiovascular Engineering and Technology. Vol 1(2): 154-164. (2010)

Paul A, Jardin BA, Kulamarva A, Malhotra M, Elias CB, Prakash S, Recombinant baculovirus as a highly potent vector for gene therapy of human colorectal carcinoma: molecular cloning, expression, and in vitro characterization. Molecular Biotechnology. Vol. 45(2): 129-39. (2010)

Urbanska AM, Paul A, Bhathena J, and Prakash S, Suppression of tumorigenesis: modulation of inflammatory cytokines by oral administration of microencapsulated probiotic yogurt. International Journal of Inflammation. Vol 2010, Article ID 894972 (2010)

Paul A and Prakash S, Baculovirus reveals a new pH-dependent direct cell-fusion pathway for cell entry and transgene delivery. Future Virology Vol. 5(5): 533-537. (2010)

Prakash S, Khan A and Paul A, Nanoscaffold based stem cell regeneration therapy: recent advancement and future potential. Expert Opin Biol Ther. Vol. 10(12): 1649-61. (2010)

Paul A, Cantor A, Shum-Tim D, Prakash S, Superior stem cell delivery features of genipin crosslinked polymeric microcapsules: preparation and in vitro characterization using human adipose stem cells. Molecular Biotechnology. 2010 Nov 30 (2010)

Chen H, Ouyang W, Martoni C, Afkhami F, Lawuyi B, Lim T and Prakash S, Investigation of genipin cross-linked microcapsule for oral delivery of live bacterial cell and other biotherapeutics: preparation and in-vitro analysis in simulated human gastrointestinal model. International Journal of Polymer Science. Vol 2010, Article ID 985137. (2010)

Afkhami F, Durocher Y and Prakash S, Investigation of anti-angiogenic tumor therapy potential of microencapsulated HEK293 VEGF165b producing cells. Journal of Biomedicine and Biotechnology. 2010: Article ID 645610. (2010)

Sebak S, Mirzaei M, Malhotra M, Kulamarva A, and Prakash S, Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis. Int. J. Nanomedicine. Vol. 2010(5): 525-532. (2010)

Coussa R, Martoni C, Bhathena C, Urbanska AM and Prakash S, Oral Microencapsulated Live Saccharomyces Cerevisiae Cells for Use in Renal Failure Uremia: Preparation and in-Vivo Analysis, Journal of Biomedicine and Biotechnol. 2010 Article ID 620827. (2010)

Paul A, El-Hayek E, Shum-Tim D, and Prakash S, Recent advancements in pharmacological stent therapy using polymeric materials: opportunities and challenges. Current Drug Delivery. Vol 7(3): 216-224. (2010)

Jones, ML, Ganopolsky JG, Labbe A, Wahl C, and Prakash S, Antimicrobial properties of nitric oxide and its application in antimicrobial formulations and medical devices. Applied Microbiology and Biotechnology Vol. 88(2): 401-407. (2010)

Jones M, Ganopolsky JG, Labbe A, and Prakash S, Novel nitric oxide producing probiotic wound healing patch and its antimicrobial efficacy: preparation and in vitro analysis. Applied Microbial Biotechnology. Vol. 87(2):509-16. (2010)

Prakash S, Malhotra M, Rengaswamy V, Nonviral siRNA delivery for gene silencing in neurodegenerative diseases. Methods Mol Biol. 2010(623): 211-29. (2010)

Singh P, Kumar P, Katyal A, Kalra R, Dass SK, Prakash S, Chandra R, Synthesis and electrochemical studies of charge-transfer complexes of thiazolidine-2,4-dione with sigma and pi acceptors. Spectrochim Acta A Mol Biomol Spectrosc. 75(3): 983-91. (2010)

Tabrizian

Fatanat-Didar T, Tabrizian M, "Adhesion based detection, sorting and enrichment of cells in microfluidic Lab-on-Chip devices", Lab on a Chip, c0lc00130a [Epub ahead of print] (2010)

Duceppe N, Tabrizian M, "Advances in using chitosan-based nanoparticles for in vitro andin vivo drug and gene delivery", Expert Opin. Drug Deliv. 7(10), 1191-1207 (2010)

Tkaczyk C, Huk OL, Mwale F, Antoniou J, Zukor DJ, Petit A, Tabrizian M, "Effect of chromium and cobalt ions on the expression of antioxidant enzymes in human U937 macrophage-like cells", J. Biomed. Mat. Res A. 94(2): 419-25 (2010)

Tkaczyk C, Huk OL, Mwale F, Antoniou J, Zukor DJ, Petit A, Tabrizian M, "Investigation of the binding of Cr(III) complexes to bovine and human serum proteins: A Proteomic Approach ", J Biomed Mater Res A. 94(1): 214-22 (2010)

Haidar ZS, Hamdy RC, Tabrizian M, "Biocompatibility and safety of a hybrid core-shell nanoparticulate OP-1 delivery system intramuscularly administered in rats". Biomaterials 31(10): 2746-54. (2010)

Daoud J, Petropavlovskaia M, Rosenberg L, Tabrizian M, "The effect of extracellular matrix components on the preservation of human islet function in vitro", Biomaterials, 31(7): 1676-82 (2010)

Haidar Z, Tabrizian M, Hamdy R, "A hybrid rhOP-1 delivery system enhances new bone regeneration and consolidation in a rabbit model of distraction osteogenesis", Growth Factors, 28(1): 44-55. (2010)

Malic L, Brassard, D, Veres T, Tabrizian M, "Detection of biochemical assays in digital microfluidic LOC devices", Lab on a Chip, 10(4): 418-31 (2010)