SM

Publications

Preprints

  • "Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures" Félix Proulx-Giraldeau, Jan M. Skotheim, Paul Francois.

2022

  • "Universal antigen encoding of T cell activation from high-dimensional cytokine dynamics" Achar SR, Bourassa FXP, Rademaker TJ, Lee A, Kondo T, Salazar-Cavazos E, Davies JS, Taylor N, François P*, Altan-Bonnet G*, 2022. 376(6595):880-884
  • "Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock" Layague Sanchez PG, Mochulska V, Mauffette Denis C, Mönke G, Tomita T, Tsuchida-Straeten N, Petersen Y, Sonnen KF, François P*, Aulehla A* (In Press)
  • "Latent space of a small genetic network: Geometry of dynamics and information" Seyboldt R, Lavoie J, Henry A, Vanaret J, Petkova MD, Gregor T, François P* .2022. 119 (26) e2113651119

2021

  • "Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling" Bergeron-Sandoval LP, Kumar S, Khadivi Heris H, Chang CLA, Hendricks AG, Cornell CE, Keller SL, François P, Hendricks AG, Ehrlicher AJ, Pappu RV, Michnick SW*. PNAS. 2021. 118 (50) e2113789118
  • "Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential" Rogers D, Sood A, Wang H, van Beek JJP, Rademaker TJ, Artusa P, Schneider C, Shen C, Wong DC, Lebel M-E, Condotta SA, Richer MJ, Martins AJ, Tsang JS, Barreiro L, François P, Langlais D, Melichar HJ, Textor J, Mandl JN*. Cell Rep. 2021. 37(9):110064

2020

  • "Geometric models for robust encoding of dynamical information into embryonic patterns" Jutras-Dubé L, El-Sherif E, François P,
  • "Numerical Parameter Space Compression and Its Application to Biophysical Models" Hsu CT, Brouhard GJ, François P, 118(6):1455-1465

2019

  • "Successive Kinesin-5 Microtubule Crosslinking and Sliding Promote Fast, Irreversible Formation of a Stereotyped Bipolar Spindle" " Leary A, Sim S, Nazarova E, Shulist K ,Genthial R, Yang SK ,Bui KH , Francois P , Vogel J
  • "Physical approaches to receptor sensing and ligand discrimination" François P, Zilman A,
  • "A High-Throughput Image Correlation Method for Rapid Analysis of Fluorophore Photoblinking and Photobleaching Rates" Sehayek S, Gidi Y, Glembockyte V, Brandão HB, François P, Cosa G, Wiseman PW,
  • "Attack and Defense in Cellular decisions: lessons from machine learning" Rademaker T, Bengio E, François P,
  • "In Silico Evolution of Biochemical Log-Response" Hemery M, François P,

2018

  • “φ-evo: A program to evolve phenotypic models of biological networks" Henry A, Hemery M, François P.
  • “Landscape, bifurcations, geometry for development" François P, Jutras-Dubé L.
  • “From evolutionary computation to phenotypic spandrels Inverse problem for immune ligand recognition" François P, Hemery M. <
  • “Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation" Sonnen KF, Lauschke VM, Uraji J, Falk HJ, Petersen Y, Funk MC, Beaupeux M, François P, Merten CA, Aulehla A.

2017

  • “Untangling the hairball: fitness based asymptotic reduction of biological networks" Proulx-Giraldeau F, Rademaker TJ, François P )
  • “Speed regulation of genetic cascades allows for evolvability in the body plan specification of insects" Zhua X, Rudolf H, Healey L, François P, Brown SJ, Klingler M, El-Sherif E,
  • “Multiscale quantification of tissue behavior during amniote embryo axis elongation" Benazeraf B, Beaupeux M, Tchernookov M, Wallingford A, Salisbury T, Shirtz A, Shirtz A, Huss D, Pourquie O, François P, Lansford R,
  • "Sorting at embryonic boundaries requires high heterotypic interfacial tension" Canty L, Zarour E, Kashkooli L, François P, Fagotto F

2016

  • “Phenotypic spandrel: absolute discrimination and ligand antagonism" François P , Hemery M, Johnson KA, Saunders LN,
  • “Positional information from oscillatory phase shifts : insights from in silico evolution" Beaupeux M, François P
  • “Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution" Rothschild JB, Tsimiklis P, Siggia ED, François P
  • “The case for absolute ligand discrimination : modeling information processing and decision by immune T cells" François P and Altan-Bonnet G,

2015

  • “Critical Timing without a Timer for Embryonic Development" Tufcea DE and François P
  • “Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity" Shih NP, François P, Delaune E and Amacher SL
  • “Chemodetection in fluctuating environments: Receptor coupling, buffering, and antagonism" Lalanne JB and François P

2014

  • “Evolving phenotypic networks in silico" François P S1084-9521(14)00185-2. (2014)

2013

  • “ Distinct roles for anti-parallel microtubule pairing and overlap during early spindle assembly." Nazarova E, O'Toole E, Kaitna S, François P, Winey M, Vogel J. Mol Biol Cell. 2013 Aug 21
  • “Principles of Adaptive Sorting Revealed by In Silico Evolution” Lalanne JB and François P, Physical Review Letters, vol. 110 no. 21 (2013),PDF icon phys_rev_lett_2013_lalanne.pdf,PDF icon supplements_v3.pdf
    See SM press release, , , etc...
  • “A phenotypic model for early T-cell activation displaying sensitivity, specificity and antagonism” François P, Voisinne G, Siggia ED, Altan-Bonnet G, Vergassola M,
  • “Scaling of embryonic patterning based on phase-gradient encoding”, Lauschke VM, Tsiairis CD, François P, Aulehla A, Nature 493, 101–105 (2013)PDF icon nature_2013_lauschke.pdf
    See also associated Nature's . This paper has been covered by and SM.

2012

  • “Single-Cell-Resolution Imaging of the Impact of Notch Signaling and Mitosis on Segmentation Clock Dynamics”, Delaune E, François P, Shih NP, Amacher SL,
    See also associated Dev Cell's . This paper has been covered by and SM.

  • “Phenotypic Models of Evolution and Development: Geometry as Destiny”, François P, Siggia ED,
  • “Pareto Evolution of Gene Networks”, Warmflash A, François P, Siggia ED,
    This paper has been selected for the of Physical Biology.
  • “Adaptive Temperature Compensation in Circadian Oscillations” François P, Despierre N, Siggia ED
  • “Evolution in silico : from network structure to bifurcation theory”, François P, Adv Exp Med Biol.751:157-82, in "Evolutionary Systems Biology", Springer (2012) O. Soyer EditorPDF icon adv._exp._med._biol._2012_francois.pdf

2010 and before

  • “Predicting embryonic patterning using mutual entropy fitness and in silico evolution” François P, Siggia E, (2010)
    This paper has been reviewed by
  • “A random cell motility gradient downstream of FGF controls elongation of an amniote embryo.”, Benazeraf B, François P, Baker R, Denans N, Little C, Pourquié O, (2010)
    This paper has been reviewed by, covered by and by the famous blog about evolution
  • “Scaling of BMP gradients in Xenopus embryos”, François P , Vonica A , Brivanlou AH, Siggia, E, Brief communication arising, Nature, 461(7260):E1; discussion E2 (2009)PDF icon nature_2009_francois.pdf
  • “A case study of evolutionary computation of biochemical adaptation”, François P, Siggia E, Physical Biology, 5 : 026009 (2008)PDF icon phys_biol_2008_francois.pdf
    This paper has been covered by
  • “Deriving structure from evolution : metazoan segmentation”, François P, Hakim V, Siggia E, (2007)
    This paper has been reviewed by.
  • “ Core genetic module: the Mixed Feedback Loop ”, François P, Hakim V,
  • “ A model for the Neurospora circadian clock ”, François P,
  • “ Design of genetic networks with specified functions by evolution in silico ”, François P, Hakim V,
    This paper has been reviewed by and by the most famous popular Science Magazine in France, Science et Vie.
  • “A matrix ansatz for the diffusion of an impurity in the asymmetric exclusion process”, Boutillier C, François P, Mallick K, Mallick S, J. Phys. A, Math. Gen, 35 (46): 9703-9730 (2002)PDF icon journal_of_physics_a_mathematical_and_general_2002_boutillier.pdf
  • “Adaptation d’échelle et gradient de phase dans un modèle ex vivo de somitogenèse”, François P. Med Sci (Paris).2013 Aug-Sep;29(8-9):696-8.
  • “Une avancée technique pour comprendre la dynamique de l’ horloge de segmentation”, Delaune E, François P, Shih NP, Amacher SL. Med Sci (Paris). 2013 Apr;29(4):355-8.
  • “A non directional cell migration gradient in the presomitic mesoderm contributes to axis elongation in chicken embryos” Benazeraf B, François P, Baker R, Denans N, Little C, Pourquié O, Biologie Aujourd'hui 205(2):95-103. (2011) doi: 10.1051/jbio/2011014
  • Review on “A Cell Biologist’s Guide to Modeling and Bioinformatics”, François P,The Quaterly Review of Biology 83 (3):311-312(2008)
  • “ Genetic networks: design in silico and applications”, François P, Physicalia Magazine (journal of the Belgian Physical Society) (2005)
  • “Ces gaz qui soufflent le chaud”, François P, Science et vie hors série Énergie (2001)

Contact

Paul François


Ernest Rutherford Physics Building, Room 221
SM
3600 rue University
Montréal, QC, Canada H3A 2T8


Tel: +1 514 398 1635Fax : +1 514 398 8434

Email: paulf at physics dot mcgill dot ca

Back to top