捆绑SM社区

About Cystic Fibrosis

捆绑SM社区

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What causes CF?


The mutated gene that causes CF encodes a chloride channel called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Defects in CFTR result in a deficiency of cAMP-stimulated chloride conductance in epithelial cells at mucosal surfaces, which leads to the dehydrated mucous secretions that are viscous and difficult to clear. Abnormal secretions lead to profound tissue inflammation, bacterial colonization, and pulmonary infection.听

What does CF听do?


CF affects most exocrine glands, notably the pancreas, and other epithelia such as the intestine, liver and bile duct. However, most morbidity and mortality results from a defect in airway mucociliary clearance, which leads to cycles of bacterial infection, chronic inflammation, fibrosis, and a decline in pulmonary function.听Despite improved antibiotics, enzyme supplements and clinical care, there is no effective treatment for this disease for most patients.

What can I do to help?


The CFTRc not only conducts research on curing CF, but also participates in a number of fundraising and awareness campaigns throughout the year such as the Carstar Walk to Make Cystic Fibrosis History in association with Cystic Fibrosis Canada and Fibrose kystique Qu茅bec and the Cystic Fibrosis Symposium. Look through the website to see what听Events听you can participate in,听Contact Us, or visit our Publications page to see the most recent update on our research.


Cystic Fibrosis is the most common fatal genetic disease affecting Caucasians

In Lac St. Jean, Quebec alone CF affects 1 in 902 newborns

Cystic Fibrosis affects 1 in 3,500 births in North America, UK, Europe, Middle East, and Australia

The most common CFTR gene mutation is听螖F508

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捆绑SM社区 is situated on the traditional territory of the Kanien鈥檏eh脿:ka, a place which has long served as a site of meeting and exchange amongst nations. We recognize and respect the Kanien鈥檏eh脿:ka as the traditional custodians of these lands and waters.

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