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Darcy Wagner

Academic title(s): 

Professor, Department of Biomedical Engineering

Professor, Department of Medicine, Division of Experimental Medicine

Canada Excellence Research Chair听in Lung Regenerative Medicine听

贵补肠耻濒迟测,听Meakins-Christie Laboratories ()

Scientist, Translational Research in Respiratory Diseases Program (RESP) at the Research Institute of the 捆绑SM社区 Health Centre ()

Principal Investigator, 捆绑SM社区 Regenerative Medicine Network ()听

Darcy Wagner
Contact Information
Address: 

Research Institute of the 捆绑SM社区 Health Centre

1001 D茅carie Blvd., Block E, Montreal, QC, CANADA H4A 3J1

Phone: 
514 934-1934 x76172
Email address: 
darcy.wagner [at] mcgill.ca
Link(s): 
Areas of expertise: 

Our lab focuses on听how the听extracellular environment听directs听stem cell听behavior听for endogenous and exogenous lung tissue regeneration. We use a multidisciplinary approach using advances in materials science (polymer design听and synthesis), manufacturing (e.g.听3D bioprinting), and听endogenous and iPSC-derived lung stem cells听to construct these new models.听

The main areas of interest of the lab are:听

  • Design and use of biologic (acellular) and synthetic scaffolds in diverse manufacturing approaches to bioengineer new lung tissue for transplantation.听

  • Understand the role of the extracellular matrix in directing lung stem cell behaviour in vivo and ex vivo during regeneration (normal and pathologic)听听

  • Build听and validate听new models of human lung tissue听and chronic lung disease听to reduce animal usage and for use as drug discovery and therapeutic screening platforms

碍别测飞辞谤诲蝉:听bioengineering, lung regeneration, biomaterials, stem cells, bioprinting, microfluidics, light sheet fluorescence microscopy, image analysis

Selected publications: 

Recent select publications:

Gvazava et al.听Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos. Journal of the American Chemical Society.听2023, 145 (45): 24796鈥�24808.

Ptasinski et al.听Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids.听Life Science Alliance. 2023, 6(8):e202201853.

Da Silva et al.听Formalin-free fixation and xylene-free tissue processing preserves cell-hydrogel interactions for histological evaluation of 3D calcium alginate tissue engineered constructs.听Front Biomaterial Science听2023, 2:1155919.

Alsafadi et al.听Simultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations.听Stem Cell Rep听2022, 17(12): 2718-2731. and

De Santis et al. Extracellular matrix reinforced bioinks for 3D bioprinting human tissue.听Adv Materials听2021, 33(3):2005476.

Complete Publication List:

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