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Josephine Nalbantoglu's research interests focus on the molecular genetics of Alzheimer's Disease, on the regulation of gene expression in the nervous system and on gene therapy for brain tumours. In the course of studying the role of amyloid metabolism and deposition in Alzheimer's Disease, her laboratory has generated transgenic mice that express a fragment of the human amyloid precursor protein (APP). These mice show signs of tissue injury and deficits in behaviour that model the changes that occur in Alzheimer's Disease. She is also studying the control of APP gene expression by characterizing important gene regulatory sequences and the proteins binding to them.聽