颁辞辞谤诲辞苍苍茅别蝉
Courriel :听stefano.stifani [at] mcgill.ca (Stefano Stifani)
T茅l : 514-398-3946
Publications r茅centes :
Affiliations acad茅miques : Neurologie et Neurochirurgie, Anatomie et Biologie cellulaire
Groupes de recherch别听:听Tumeurs c茅r茅brales,听Maladies neuro-immunologiques
Les objectifs des travaux effectu茅s au laboratoire du Pr Stefano Stifani sont les suivants.
- Comprendre les m茅canismes mol茅culaires qui r茅gulent l鈥檃utorenouvellement, la prolif茅ration et la diff茅renciation de cellules prog茅nitrices/souches neuronales (NSPC) dans le cerveau en d茅veloppement et postnatal, avec un int茅r锚t particulier pour le cortex c茅r茅bral.
- Caract茅riser les m茅canismes mol茅culaires sous-jacents 脿 la croissance et 脿 la propagation de la forme la plus maligne du cancer du cerveau, le glioblastome.
- Faire la lumi猫re sur les 茅v茅nements mol茅culaires contr么lant le d茅veloppement et l鈥檌nt茅gration des circuits neuronaux de divers sous-types de cellules nerveuses motrices (motoneurones), avec un int茅r锚t particulier pour les cellules vuln茅rables 脿 la d茅g茅n茅rescence dans les maladies des motoneurones comme la scl茅rose lat茅rale amyotrophique.
S茅lection de publications:听
Murthy, M., Bocking, S., Verginelli, F., and Stifani S. (2014) Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells. Gene. 540(2):191-200. doi: 10.1016/j.gene.2014.02.038. Epub 2014 Feb 26.
Ciarapica, R., Carcarino, E., Adesso, L., De Salvo, M., Bracaglia, G., Leoncini, P.P., Dall鈥橝gnese, A., Verginelli, F., Milano, G.M., Boldrini, R., Inserra, A., Stifani, S., Screpanti, I, Marquez, V.E., Valente, S., Mai, A., Puri, P.L., Locatelli, F., Palacios, D., Rota R. (2014) Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS. BMC Cancer. 14(1):139. doi: 10.1186/1471-2407-14-139.
Verginelli, F., Perin, A., Dali, R., Fung, K.H., Lo, R., Longatti, P., Guiot, M.C., Del Maestro, R.F., Rossi. S., di Porzio, U., Stechishin, O., Weiss, S., Stifani, S. (2013) Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth. Nature Commun. Dec 20;4:2956. doi: 10.1038/ncomms3956.
Perez-Campo, F.M., Costa, G., Lie-a-Ling, M., Stifani, S., Kouskoff, V., and Lacaud, G. (2014) MOZ-mediated repression of p16INK4a is critical for the self-renewal of neural and 听听听听听听听听听听 hematopoietic stem cells. Stem Cells 32:1591-1601. doi: 10.1002/stem.1606. Epub 2013 Dec 4.
Ciarapica, R., Methot, L., Tang, Y., Lo, R., Dali, R., Buscarlet, M., Locatelli, F., Del Sal, G., Rota, R., and Stifani, S. (2014) Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation. Cell Death Differ. 21(2):321-32. doi: 10.1038/cdd.2013.160. Epub 2013 Nov 22.
Ciarapica R., Bracaglia G., De Salvo M., Carcarino, E., Adesso, L., Leoncini P., Dall'Agnese 听听听听听听 A., Walters, Z., Verginelli F., De Sio L., Boldrini R., Inserra A, Bisogno G., Rosolen A., Alaggio R., Ferrari A., Collini P., Locatelli M., Stifani S., Screpanti I., Rutella S., Yu, Q., Marquez V., Shipley, J., Valente, S., Mai, A., Miele L., Puri P.L., Locatelli F., Palacios D., and Rota, S. (2014) Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx). Oncogene. 33(32):4173-84. doi: 10.1038/onc.2013.471. Epub 2013 Nov 11.
Methot, L., Hermann, R., Tang, Y., Lo, R., Al-Jehani, H., Jhas, S., Svoboda, D., Slack, R.S., Barker, P.A., and Stifani, S. (2013) Functional Interaction and Antagonistic Roles of NF-kappaB and Hes6 in the Regulation of Cortical Neurogenesis. Mol Cell Biol. 33:2797-2808. doi: 10.1128/MCB.01610-12. Epub 2013 May 20.
Zusso, M., Methot, L., Lo, R., Grenhalgh, A.D., David, S., and Stifani, S. (2012) Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1. J Neurosci. 32(33), 11285-11298.
Dastidar, S.G., Narayanan, S., Stifani, S., and D鈥橫ello, S. (2012) TLE1 combines with FoxG1 to promote neuronal survival. J Biol Chem. 287(18):14749-14759. Epub 2012 Feb 21.
Todd, K.J., Lan-Chow-Wing, N., Salin-Cantegrel, A., Cotter, A., Zagami, C.J., Lo R., and Stifani, S. (2012) Establishment of motor neuron-V3 interneuron progenitor domain boundary in the ventral spinal cord requires Groucho-mediated transcriptional corepression. PLoS One 7(2) e31176. Epub 2012 Feb 17.
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