Edith Hamel, PhD
Edith Hamel's research focused on the interactions between neurons, astrocytes and microvessels that assure a proper blood supply to activated brain areas, a phenomenon commonly referred to 鈥渘eurovascular coupling.鈥濃�疶hese interactions are at the basis of several brain-imaging techniques that use hemodynamic signals to map changes in brain activity under physiological and pathological conditions. The underlying cellular mechanisms and chemical mediators of these signals are poorly understood. This is important because the dysfunction of specific populations of cells might have dramatic repercussions on the regulation of local blood flow. Moreover, several neurological conditions are associated with a cerebrovascular pathology and impaired neurovascular coupling responses.听
Edith Hamel is currently Professor Emerita and part-time Post-retirement Professor.听
Royea J, Zhang L, Tong X-K, Hamel E (2017) The angiotensin IV receptor: a potential target for cerebrovascular and cognitive rescue in a mouse model of Alzheimer's disease. J Neurosci 37(32):5562-5573.听
Haqqani AS, Mianoor Z, Star AT, Detcheverry F, Delaney CE, Stanimirovic DB, Hamel E, Badhwar A (2023) Proteomic profiling of brain vessels in a mouse model of cerebrovascular pathology. Biology, Dec 7;12(12):1500.听
Tong X-K, Royea J, Hamel E (2022) Simvastatin rescues memory and granule cell maturation through the Wnt/飦�-catenin signaling pathway in a mouse model of Alzheimer disease. Cell Death and Disease 13(4): 325.听
Trigiani LJ, Bourourou M, Lacalle-Aurioles M, Lecrux C, Hynes A, Spring S, Fernandes DJ, Sled JG, Lesage F, Schwaninger M, Hamel E. (2022) A functional cerebral endothelium is necessary to protect against cognitive decline. J Cereb Blood Flow and Metabol 42(1): 74-89.听听
Trigiani LJ, Lacalle-Aurioles M, Bourourou M, Lijun L, Greenhalgh AD, Zarruk JG, David S, Fehlings MG, Hamel E (2020) Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia. Glia Sep; 68(9):1925-1940听
Tong X-K, Trigiani L, Hamel E (2019) High cholesterol triggers white matter alterations and cognitive deficits in a mouse model of cerebrovascular disease: benefits of simvastatin. Cell Death Dis, Jan 28;10(2):89.听
Badhwar A, Brown R, Stanimirovic DB, Haqqani AS, Hamel E (2017). Proteomic differences in brain vessels of Alzheimer鈥檚 disease mice: normalization by PPAR纬 agonist pioglitazone. J Cereb Blood Flow Metab 37 (3): 1120-1136.听听
