Killam Seminar Series presents "Towards a More Authentic Vision of the (multi)Coding Potential of RNA"
Xavier Roucou will present, 鈥淭owards a more authentic vision of the (multi)coding potential of RNA".
Registration available .
Speaker: Xavier Roucou, PhD
Professor and Department Chair, Department of Biochemistry and Functional Genomics, Universit茅 de Sherbrooke
Canada Research Chair in Functional Proteomics and Discovery of Novel Proteins
础产蝉迟谤补肠迟:听Ten of thousands of open reading frames (ORFs) are hidden within transcripts. They have eluded annotations because they are either small or within unsuspected locations. These are named alternative ORFs (altORFs) or small ORFs and have recently been highlighted by innovative proteogenomic approaches, such as our OpenProt resource, revealing their existence and implications in biological functions. Due to the absence of altORFs from annotations, pathogenic mutations within these are being ignored. I will discuss our latest progress on the re-analysis of large-scale proteomics datasets to improve our knowledge of proteomic diversity, and the functional characterization of a second protein coded by the FUS gene.听Finally, I will explain the need to map the coding potential of the transcriptome using artificial intelligence rather than with conventional annotations that do not capture the full translational activity of ribosomes.
Supported by the generosity of the Killam Trusts , The Neuro鈥檚 Killam Seminar series hosts outstanding guest speakers whose research is of interest to the scientific community at The Neuro and 捆绑SM社区.
