Simon Tran
Dr. Tran is experienced in all three fields of research: basic science, translational research, and clinical studies. He is committed to the training of graduate and postdoctoral students in the area of stem cell biology and tissue engineering. The aim of this laboratory is to identify, isolate, and characterize post-natal stem cells of the craniofacial complex (such as salivary and periodontal stem cells). We are also working on the growth and behavior of post-natal stem cell on different 3-D tissue engineered matrices. Our hypothesis is that post-natal stem cells from one tissue (such as stem cells from the bone marrow) can differentiate into cells of another tissue (such as the salivary gland) and how to translate this phenomenon into clinically useful therapies to regenerate lost salivary gland tissue of patients experiencing the disabling effects of a dry mouth (i.e. reduced salivary secretion) due to Sjogren鈥檚 Syndrome or to the damage caused to the salivary glands following irradiation treatment for head and neck cancer. In addition to providing a new understanding of tissue dynamics in health and disease, the Tran鈥檚 laboratory presents unique possibilities for the emerging field of regenerative medicine.
- Tissue engineering
- Stem cell
- Saliva
- Regenerative medicine
- Translational research
- Periodontal diseases
1. Zhang Y, Pham HM, Tran SD: The Chicken Egg: An Advanced Material for Tissue Engineering. Biomolecules 2024, 14(4).
2. Wu KY, Tabari A, Mazerolle 脡, Tran SD: Towards Precision Ophthalmology: The Role of 3D Printing and Bioprinting in Oculoplastic Surgery, Retinal, Corneal, and Glaucoma Treatment. Biomimetics (Basel) 2024, 9(3).
3. Wu KY, Serhan O, Faucher A, Tran SD: Advances in Sj枚gren's Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms. Biomolecules 2024, 14(1).
4. Wu KY, Fujioka JK, Goodyear E, Tran SD: Polymers and Biomaterials for Posterior Lamella of the Eyelid and the Lacrimal System. Polymers (Basel) 2024, 16(3).
5. Upadhyay A, Tsamchoe M, Tran SD: Salivary Organotypic Tissue Culture: An Ex-vivo 3D Model for Studying Radiation-Induced Injury of Human Salivary Glands. Methods in molecular biology (Clifton, NJ) 2024, 2749:39-54.
6. Tran SD: Artificial intelligence, cell therapies, acupuncture, and tight junctions: Advances in salivary research. Oral Dis 2024, 30(1):63-64.
7. Pillai S, Munguia-Lopez JG, Tran SD: Bioengineered Salivary Gland Microtissues鈹�A Review of 3D Cellular Models and their Applications. ACS applied bio materials 2024.
8. Kishimoto N, Ujita T, Tran SD, Sanuki T, Seo K: Simulation training for medical emergencies: Evaluation of dentists' long-term learning skills and confidence. Eur J Dent Educ 2024, 28(2):689-697.
9. I T, Kanai R, Hasegawa K, Ogaeri T, Tran SD, Sumita Y: Recent progress in regenerative therapy for damaged salivary glands: From bench to bedside. Oral Dis 2024, 30(1):38-49.
10. Zhou WBS, Shi XQ, Liu Y, Tran SD, Beaudry F, Zhang J: Unbiased proteomic analysis detects painful systemic inflammatory profile in the serum of nerve-injured mice. Pain 2023, 164(2):e77-e90.
11. Wu KY, Tan K, Akbar D, Choulakian MY, Tran SD: A New Era in Ocular Therapeutics: Advanced Drug Delivery Systems for Uveitis and Neuro-Ophthalmologic Conditions. Pharmaceutics 2023, 15(7).
12. Wu KY, Mina M, Carbonneau M, Marchand M, Tran SD: Advancements in Wearable and Implantable Intraocular Pressure Biosensors for Ophthalmology: A Comprehensive Review. Micromachines (Basel) 2023, 14(10).
13. Wu KY, Kulbay M, Tanasescu C, Jiao B, Nguyen BH, Tran SD: An Overview of the Dry Eye Disease in Sj枚gren's Syndrome Using Our Current Molecular Understanding. Int J Mol Sci 2023, 24(2).
14. Wu KY, Joly-Chevrier M, Akbar D, Tran SD: Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems. Pharmaceutics 2023, 15(4).
15. Wu KY, Fujioka JK, Gholamian T, Zaharia M, Tran SD: Suprachoroidal Injection: A Novel Approach for Targeted Drug Delivery. Pharmaceuticals (Basel, Switzerland) 2023, 16(9).
16. Wu KY, Brister D, B茅langer P, Tran SD: Exploring the Potential of Nanoporous Materials for Advancing Ophthalmic Treatments. Int J Mol Sci 2023, 24(21).
17. Wu KY, Ashkar S, Jain S, Marchand M, Tran SD: Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma. Polymers (Basel) 2023, 15(6).
18. Wu KY, Akbar D, Giunta M, Kalevar A, Tran SD: Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges. Materials (Basel) 2023, 17(1).
19. Wu KY, Ahmad H, Lin G, Carbonneau M, Tran SD: Mesenchymal Stem Cell-Derived Exosomes in Ophthalmology: A Comprehensive Review. Pharmaceutics 2023, 15(4).
20. Upadhyay A, Tran SD: Stem cell therapy for salivary gland regeneration after radiation injury. Expert opinion on biological therapy 2023, 23(6):455-460.
21. Upadhyay A, Cao UMN, Hariharan A, Almansoori A, Tran SD: Gene Therapeutic Delivery to the Salivary Glands. Adv Exp Med Biol 2023, 1436:55-68.
22. Su X, Upadhyay A, Tran SD, Lin Z: Cell-Free Therapies: The Use of Cell Extracts to Mitigate Irradiation-Injured Salivary Glands. Biology (Basel) 2023, 12(2).
23. Pillai S, Kwan JC, Yaziji F, Yu H, Tran SD: Mapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers. Cancers (Basel) 2023, 15(15).
24. Min H, Zhu S, Safi L, Alkourdi M, Nguyen BH, Upadhyay A, Tran SD: Salivary Diagnostics in Pediatrics and the Status of Saliva-Based Biosensors. Biosensors (Basel) 2023, 13(2).
25. Lin Y, Fu ML, Harb I, Ma LX, Tran SD: Functional Biomaterials for Local Control of Orthodontic Tooth Movement. Journal of functional biomaterials 2023, 14(6).
26. Kwan JC, Dondani J, Iyer J, Muaddi HA, Nguyen TT, Tran SD: Biomimicry and 3D-Printing of Mussel Adhesive Proteins for Regeneration of the Periodontium-A Review. Biomimetics (Basel) 2023, 8(1).
27. Kort-Mascort J, Shen ML, Martin E, Flores-Torres S, Pardo LA, Siegel PM, Tran SD, Kinsella J: Bioprinted cancer-stromalin-vitromodels in a decellularized ECM-based bioink exhibit progressive remodeling and maturation. Biomedical materials (Bristol, England) 2023, 18(4).
28. Kort-Mascort J, Flores-Torres S, Peza-Chavez O, Jang JH, Pardo LA, Tran SD, Kinsella J: Decellularized ECM hydrogels: prior use considerations, applications, and opportunities in tissue engineering and biofabrication. Biomater Sci 2023, 11(2):400-431.
29. Kishimoto N, Sanuki T, Liu Y, Tran SD, Seo K: Simulation training for medical emergencies of dental patients: A review of the dental literature. The Japanese dental science review 2023, 59:104-113.
30. Iyer J, Pillai S, Munguia-Lopez JG, Zhang Y, Mielkozorova M, Tran SD: Salivary gland bioengineering - yesterday, today, tomorrow! Histology and histopathology 2023, 38(6):607-621.
31. Honma R, I T, Seki M, Iwatake M, Ogaeri T, Hasegawa K, Ohba S, Tran SD, Asahina I, Sumita Y: Immunomodulatory Macrophages Enable E-MNC Therapy for Radiation-Induced Salivary Gland Hypofunction. Cells 2023, 12(10).
32. Hasegawa K, Raudales JLM, I T, Yoshida T, Honma R, Iwatake M, Tran SD, Seki M, Asahina I, Sumita Y: Effective-mononuclear cell (E-MNC) therapy alleviates salivary gland damage by suppressing lymphocyte infiltration in Sj枚gren-like disease. Frontiers in bioengineering and biotechnology 2023, 11:1144624.
33. Hariharan A, Tran SD: Localized Drug Delivery Systems: An Update on Treatment Options for Head and Neck Squamous Cell Carcinomas. Pharmaceutics 2023, 15(7).
34. Dondani JR, Iyer J, Tran SD: Surface Treatments of PEEK for Osseointegration to Bone. Biomolecules 2023, 13(3).
35. Cao UMN, Zhang Y, Chen J, Sayson D, Pillai S, Tran SD: Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication. Int J Mol Sci 2023, 24(4).
36. Badwelan M, Muaddi H, Ahmed A, Lee KT, Tran SD: Oral Squamous Cell Carcinoma and Concomitant Primary Tumors, What Do We Know? A Review of the Literature. Current oncology (Toronto, Ont) 2023, 30(4):3721-3734.
37. Almansoori AA, Hariharan A, Cao UMN, Upadhyay A, Tran SD: Drug Therapeutics Delivery to the Salivary Glands: Intraglandular and Intraductal Injections. Adv Exp Med Biol 2023, 1436:119-130.
38. Alli BY, Madathil S, Tran SD, Nicolau B: Protocol: carrageenan for the prevention of oral HPV infection - a feasibility randomised clinical trial. BMJ open 2023, 13(7):e074498.
39. Wu KY, Chen WT, Chu-B茅dard YK, Patel G, Tran SD: Management of Sjogren's Dry Eye Disease-Advances in Ocular Drug Delivery Offering a New Hope. Pharmaceutics 2022, 15(1).
40. Wang Y, Upadhyay A, Pillai S, Khayambashi P, Tran SD: Saliva as a diagnostic specimen for SARS-CoV-2 detection: A scoping review. Oral Dis 2022, 28 Suppl 2:2362-2390.
41. Tauer JT, Al-Jallad H, Umebayashi M, Bakhsh D, Rauch D, Tran SD, Rauch F, Hamdy R: Characterization and functional analysis of the adipose tissue-derived stromal vascular fraction of pediatric patients with osteogenesis imperfecta. Sci Rep 2022, 12(1):2414.
42. Su X, Pillai S, Liu Y, Tran SD: Isolation, Culture, and Characterization of Primary Salivary Gland Cells. Curr Protoc 2022, 2(7):e479.
43. Su X, Liu Y, ElKashty O, Seuntjens J, Yamada KM, Tran SD: Human Bone Marrow Cell Extracts Mitigate Radiation Injury to Salivary Gland. J Dent Res 2022, 101(13):1645-1653.
44. Pillai S, Munguia-Lopez JG, Tran SD: Hydrogels for Salivary Gland Tissue Engineering. Gels 2022, 8(11).
45. Morsi H, Golizeh M, Brosseau N, Janati AI, Emami E, Ndao M, Tran SD: Detection of Fusobacterium nucleatum subspecies in the saliva of pre-colorectal cancer patients, using tandem mass spectrometry. Arch Oral Biol 2022, 134:105337.
46. Idrissi Janati A, Karp I, Von Renteln D, Bouin M, Liu Y, Tran SD, Emami E: Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study. Sci Rep 2022, 12(1):5622.
47. Hajiabbas M, D'Agostino C, Simi艅ska-Stanny J, Tran SD, Shavandi A, Delporte C: Bioengineering in salivary gland regeneration. J Biomed Sci 2022, 29(1):35.
48. Buck E, Lee S, Gao Q, Tran SD, Tamimi F, Stone LS, Cerruti M: The Role of Surface Chemistry in the Osseointegration of PEEK Implants. ACS Biomater Sci Eng 2022, 8(4):1506-1521.
49. Alli BY, Upadhyay A, Zhang Y, Nicolau B, Tran SD: In Vitro Toxicity Evaluation of Carrageenan on Cells and Tissues of the Oral Cavity. Mar Drugs 2022, 20(8).
50. Wu KY, Wu DT, Nguyen TT, Tran SD: COVID-19's impact on private practice and academic dentistry in North America. Oral Dis 2021, 27 Suppl 3(Suppl 3):684-687.
51. Wu DT, Munguia-Lopez JG, Cho YW, Ma X, Song V, Zhu Z, Tran SD: Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine. Molecules 2021, 26(22).
52. Smith S, ElKashty O, Tamimi F, Tran SD, Cerruti M: Titanium-Containing Silicate-Based Sol-Gel Bioactive Glass: Development, Characterization, and Applications. Langmuir 2021, 37(49):14243-14253.
53. Pillai S, Upadhyay A, Sayson D, Nguyen BH, Tran SD: Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring. Molecules 2021, 27(1).
54. Pillai S, Upadhyay A, Khayambashi P, Farooq I, Sabri H, Tarar M, Lee KT, Harb I, Zhou S, Wang Y et al: Dental 3D-Printing: Transferring Art from the Laboratories to the Clinics. Polymers (Basel) 2021, 13(1).
55. Pham HM, Zhang Y, Munguia-Lopez JG, Tran SD: Egg White Alginate as a Novel Scaffold Biomaterial for 3D Salivary Cell Culturing. Biomimetics (Basel) 2021, 7(1).
56. Lin KT, Wang A, Nguyen AB, Iyer J, Tran SD: Recent Advances in Hydrogels: Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular Adhesives. Biomedicines 2021, 9(9).
57. Kort-Mascort J, Bao G, Elkashty O, Flores-Torres S, Munguia-Lopez JG, Jiang T, Ehrlicher AJ, Mongeau L, Tran SD, Kinsella JM: Decellularized Extracellular Matrix Composite Hydrogel Bioinks for the Development of 3D Bioprinted Head and Neck in Vitro Tumor Models. ACS Biomater Sci Eng 2021, 7(11):5288-5300.
58. Kishimoto N, Nguyen BH, Tran SD, Seo K: Telesimulation training applying flipped classroom in the dental clinic for medical emergencies. J Dent Anesth Pain Med 2021, 21(2):179-181.
59. Khayambashi P, Iyer J, Pillai S, Upadhyay A, Zhang Y, Tran SD: Hydrogel Encapsulation of Mesenchymal Stem Cells and Their Derived Exosomes for Tissue Engineering. Int J Mol Sci 2021, 22(2).
60. Iyer J, Hariharan A, Cao UMN, Mai CTT, Wang A, Khayambashi P, Nguyen BH, Safi L, Tran SD: An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches. Cancers (Basel) 2021, 13(15).
61. Hariharan A, Iyer J, Wang A, Tran SD: Tracking of Oral and Craniofacial Stem Cells in Tissue Development, Regeneration, and Diseases. Curr Osteoporos Rep 2021, 19(6):656-668.
62. Elkashty OA, Tran SD: Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment. Curr Med Sci 2021, 41(2):250-269.
63. Elkashty OA, Hariharan A, Tran SD: Aging, stem cells and cancer updated. Aging (Albany NY) 2021, 13(17):20854-20855.
64. Charbonneau AM, 脜str枚m P, Salo T, Roy S, Tran SD: Axolotls' and Mices' Oral-Maxillofacial Trephining Wounds Heal Differently. Cells Tissues Organs 2021, 210(4):260-274.
65. Al-Hamed FS, Rodan R, Ramirez-Garcialuna JL, Elkashty O, Al-Shahrani N, Tran SD, Lordkipanidz茅 M, Kaartinen M, Badran Z, Tamimi F: The effect of aging on the bone healing properties of blood plasma. Injury 2021, 52(7):1697-1708.
66. Al-Hamed FS, Abu-Nada L, Rodan R, Sarrigiannidis S, Ramirez-Garcialuna JL, Moussa H, Elkashty O, Gao Q, Basiri T, Baca L et al: Differences in platelet-rich plasma composition influence bone healing. J Clin Periodontol 2021, 48(12):1613-1623.
67. Abughanam G, Maria OM, Tran SD: Studying Sj枚gren's syndrome in mice: What is the best available model? J Oral Biol Craniofac Res 2021, 11(2):245-255.
68. Zhang Y, Pham HM, Munguia-Lopez JG, Kinsella JM, Tran SD: The Optimization of a Novel Hydrogel-Egg White-Alginate for 2.5D Tissue Engineering of Salivary Spheroid-Like Structure. Molecules 2020, 25(23).
69. Wu DT, Wu KY, Nguyen TT, Tran SD: The impact of COVID-19 on dental education in North America-Where do we go next? Eur J Dent Educ 2020, 24(4):825-827.
70. Upadhyay A, Pillai S, Khayambashi P, Sabri H, Lee KT, Tarar M, Zhou S, Harb I, Tran SD: Biomimetic Aspects of Oral and Dentofacial Regeneration. Biomimetics (Basel) 2020, 5(4).
71. Su X, Liu Y, Bakkar M, ElKashty O, El-Hakim M, Seuntjens J, Tran SD: Labial Stem Cell Extract Mitigates Injury to Irradiated Salivary Glands. J Dent Res 2020, 99(3):293-301.
72. Elkashty OA, Tran SD: Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma. Br J Cancer 2020, 123(9):1395-1403.
73. Elkashty OA, Abu Elghanam G, Su X, Liu Y, Chauvin PJ, Tran SD: Cancer stem cells enrichment with surface markers CD271 and CD44 in human head and neck squamous cell carcinomas. Carcinogenesis 2020, 41(4):458-466.
74. D'Agostino C, Elkashty OA, Chivasso C, Perret J, Tran SD, Delporte C: Insight into Salivary Gland Aquaporins. Cells 2020, 9(6).
75. Charbonneau AM, Tran SD: 3D Cell Culture of Human Salivary Glands Using Nature-Inspired Functional Biomaterials: The Egg Yolk Plasma and Egg White. Materials (Basel) 2020, 13(21).
76. Almansoori AA, Kim B, Lee JH, Tran SD: Tissue Engineering of Oral Mucosa and Salivary Gland: Disease Modeling and Clinical Applications. Micromachines (Basel) 2020, 11(12).
77. Al-Hamed FS, Maria OM, Phan J, Al Subaie A, Gao Q, Mansour A, Abu Nada L, Boukhatem I, Elkashty OA, Tran SD et al: Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model. Biomolecules 2020, 10(9).
78. Tran SD, Bakkar MO, Sumita Y, Kishimoto N: Regenerative dentistry in periodontics. Saudi Dent J 2019, 31(3):301-302.
79. Tao O, Kort-Mascort J, Lin Y, Pham HM, Charbonneau AM, ElKashty OA, Kinsella JM, Tran SD: The Applications of 3D Printing for Craniofacial Tissue Engineering. Micromachines (Basel) 2019, 10(7).
80. Seo YJ, Lilliu MA, Abu Elghanam G, Nguyen TT, Liu Y, Lee JC, Presley JF, Zeitouni A, El-Hakim M, Tran SD: Cell culture of differentiated human salivary epithelial cells in a serum-free and scalable suspension system: The salivary functional units model. J Tissue Eng Regen Med 2019, 13(9):1559-1570.
81. Mantha S, Pillai S, Khayambashi P, Upadhyay A, Zhang Y, Tao O, Pham HM, Tran SD: Smart Hydrogels in Tissue Engineering and Regenerative Medicine. Materials (Basel) 2019, 12(20).
82. Mansour A, Abu-Nada L, Al-Waeli H, Mezour MA, Abdallah MN, Kinsella JM, Kort-Mascort J, Henderson JE, Ramirez-Garcialuna JL, Tran SD et al: Bone extracts immunomodulate and enhance the regenerative performance of dicalcium phosphates bioceramics. Acta Biomater 2019, 89:343-358.
83. Lin Y, Umebayashi M, Abdallah MN, Dong G, Roskies MG, Zhao YF, Murshed M, Zhang Z, Tran SD: Combination of polyetherketoneketone scaffold and human mesenchymal stem cells from temporomandibular joint synovial fluid enhances bone regeneration. Sci Rep 2019, 9(1):472.
84. Kumari A, Wu DT, Motiani KK, Wu KY, Palumbo M, Tran SD: Career pathways and professional skills of postgraduate students from a dental research-intensive programme. Eur J Dent Educ 2019, 23(2):143-150.
85. I T, Sumita Y, Yoshida T, Honma R, Iwatake M, Raudales JLM, Shizuno T, Kuroshima S, Masuda H, Seki M et al: Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands. Stem cell research & therapy 2019, 10(1):304.
86. Elkashty OA, Ashry R, Tran SD: Head and neck cancer management and cancer stem cells implication. Saudi Dent J 2019, 31(4):395-416.
87. Charbonneau AM, Kinsella JM, Tran SD: 3D Cultures of Salivary Gland Cells in Native or Gelled Egg Yolk Plasma, Combined with Egg White and 3D-Printing of Gelled Egg Yolk Plasma. Materials (Basel) 2019, 12(21).
88. Charbonneau AM, Al-Samadi A, Salo T, Tran SD: 3D Culture Histology Cryosectioned Well Insert Technology Preserves the Structural Relationship between Cells and Biomaterials for Time-Lapse Analysis of 3D Cultures. Biotechnol J 2019, 14(11):e1900105.
89. Abughanam G, Elkashty OA, Liu Y, Bakkar MO, Tran SD: Mesenchymal Stem Cells Extract (MSCsE)-Based Therapy Alleviates Xerostomia and Keratoconjunctivitis Sicca in Sjogren's Syndrome-Like Disease. Int J Mol Sci 2019, 20(19).
90. Su X, Fang D, Liu Y, Ruan G, Seuntjens J, Kinsella JM, Tran SD: Lyophilized bone marrow cell extract functionally restores irradiation-injured salivary glands. Oral Dis 2018, 24(1-2):202-206.
91. Lin LC, Elkashty O, Ramamoorthi M, Trinh N, Liu Y, Sunavala-Dossabhoy G, Pranzatelli T, Michael DG, Chivasso C, Perret J et al: Cross-contamination of the human salivary gland HSG cell line with HeLa cells: A STR analysis study. Oral Dis 2018, 24(8):1477-1483.
92. Kishimoto N, Honda Y, Momota Y, Tran SD: Dedifferentiated Fat (DFAT) cells: A cell source for oral and maxillofacial tissue engineering. Oral Dis 2018, 24(7):1161-1167.
93. K芒 K, Rousseau MC, Tran SD, Henderson M, Nicolau B: Association between metabolic syndrome and gingival inflammation in obese children. Int J Dent Hyg 2018, 16(3):397-403.
94. Fang D, Su X, Liu Y, Lee JC, Seuntjens J, Tran SD: Cell extracts from spleen and adipose tissues restore function to irradiation-injured salivary glands. J Tissue Eng Regen Med 2018, 12(2):e1289-e1296.
95. Fang D, Shang S, Liu Y, Bakkar M, Sumita Y, Seuntjens J, Tran SD: Optimal timing and frequency of bone marrow soup therapy for functional restoration of salivary glands injured by single-dose or fractionated irradiation. J Tissue Eng Regen Med 2018, 12(2):e1195-e1205.
96. Elkashty OA, Ashry R, Elghanam GA, Pham HM, Su X, Stegen C, Tran SD: Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas. Med Oncol 2018, 35(9):124.
97. Abdallah MN, Abughanam G, Tran SD, Sheikh Z, Mezour MA, Basiri T, Xiao Y, Cerruti M, Siqueira WL, Tamimi F: Comparative adsorption profiles of basal lamina proteome and gingival cells onto dental and titanium surfaces. Acta Biomater 2018, 73:547-558.
98. Abdallah MN, Abdollahi S, Laurenti M, Fang D, Tran SD, Cerruti M, Tamimi F: Scaffolds for epithelial tissue engineering customized in elastomeric molds. J Biomed Mater Res B Appl Biomater 2018, 106(2):880-890.
99. Vorstenbosch J, Nguyen CM, Zhou S, Seo YJ, Siblini A, Finnson KW, Bizet AA, Tran SD, Philip A: Overexpression of CD109 in the Epidermis Differentially Regulates ALK1 Versus ALK5 Signaling and Modulates Extracellular Matrix Synthesis in the Skin. J Invest Dermatol 2017, 137(3):641-649.
100. Tran SD, Nguyen BH: Human umbilical cord blood hematopoietic stem cell expansion by the RNA-binding protein Musashi-2. Oral Dis 2017, 23(5):548-550.
101. Roskies MG, Fang D, Abdallah MN, Charbonneau AM, Cohen N, Jordan JO, Hier MP, Mlynarek A, Tamimi F, Tran SD: Three-dimensionally printed polyetherketoneketone scaffolds with mesenchymal stem cells for the reconstruction of critical-sized mandibular defects. Laryngoscope 2017, 127(11):E392-e398.
102. Maria OM, Liu Y, El-Hakim M, Zeitouni A, Tran SD: The role of human fibronectin- or placenta basement membrane extract-based gels in favouring the formation of polarized salivary acinar-like structures. J Tissue Eng Regen Med 2017, 11(9):2643-2657.
103. Fang D, Roskies M, Abdallah MN, Bakkar M, Jordan J, Lin LC, Tamimi F, Tran SD: Three-Dimensional Printed Scaffolds with Multipotent Mesenchymal Stromal Cells for Rabbit Mandibular Reconstruction and Engineering. Methods in molecular biology (Clifton, NJ) 2017, 1553:273-291.
104. Elghanam GA, Liu Y, Khalili S, Fang D, Tran SD: Compact Bone-Derived Multipotent Mesenchymal Stromal Cells (MSCs) for the Treatment of Sjogren's-like Disease in NOD Mice. Methods in molecular biology (Clifton, NJ) 2017, 1553:25-39.
105. Bakkar M, Liu Y, Fang D, Stegen C, Su X, Ramamoorthi M, Lin LC, Kawasaki T, Makhoul N, Pham H et al: A Simplified and Systematic Method to Isolate, Culture, and Characterize Multiple Types of Human Dental Stem Cells from a Single Tooth. Methods in molecular biology (Clifton, NJ) 2017, 1553:191-207.
106. Abdallah MN, Tran SD, Abughanam G, Laurenti M, Zuanazzi D, Mezour MA, Xiao Y, Cerruti M, Siqueira WL, Tamimi F: Biomaterial surface proteomic signature determines interaction with epithelial cells. Acta Biomater 2017, 54:150-163.
107. Su X, Fang D, Liu Y, Ramamoorthi M, Zeitouni A, Chen W, Tran SD: Three-dimensional organotypic culture of human salivary glands: the slice culture model. Oral Dis 2016, 22(7):639-648.
108. Roskies M, Jordan JO, Fang D, Abdallah MN, Hier MP, Mlynarek A, Tamimi F, Tran SD: Improving PEEK bioactivity for craniofacial reconstruction using a 3D printed scaffold embedded with mesenchymal stem cells. J Biomater Appl 2016, 31(1):132-139.
109. Lilliu MA, Seo YJ, Isola M, Charbonneau AM, Zeitouni A, El-Hakim M, Tran SD: Natural extracellular matrix scaffolds recycled from human salivary digests: a morphometric study. Oral Dis 2016, 22(4):313-323.
110. Javaid MA, Ahmed AS, Durand R, Tran SD: Saliva as a diagnostic tool for oral and systemic diseases. J Oral Biol Craniofac Res 2016, 6(1):66-75.
111. Charbonneau AM, Roy S, Tran SD: Oral-Facial Tissue Reconstruction in the Regenerative Axolotl. Journal of experimental zoology Part B, Molecular and developmental evolution 2016, 326(8):489-502.
112. Beaudin A, Emami E, Palumbo M, Tran SD: Quality of supervision: postgraduate dental research trainees' perspectives. Eur J Dent Educ 2016, 20(1):32-38.
113. Xie X, Hu K, Fang D, Shang L, Tran SD, Cerruti M: Graphene and hydroxyapatite self-assemble into homogeneous, free standing nanocomposite hydrogels for bone tissue engineering. Nanoscale 2015, 7(17):7992-8002.
114. Xia D, Qu X, Tran SD, Schmidt LL, Qin L, Zhang C, Cui X, Deng D, Wang S: Histological characteristics following a long-term nitrate-rich diet in miniature pigs with parotid atrophy. Int J Clin Exp Pathol 2015, 8(6):6225-6234.
115. Ramamoorthi M, Bakkar M, Jordan J, Tran SD: Osteogenic Potential of Dental Mesenchymal Stem Cells in Preclinical Studies: A Systematic Review Using Modified ARRIVE and CONSORT Guidelines. Stem Cells Int 2015, 2015:378368.
116. Nguyen CM, Kim JW, Quan VH, Nguyen BH, Tran SD: Periodontal associations in cardiovascular diseases: The latest evidence and understanding. J Oral Biol Craniofac Res 2015, 5(3):203-206.
117. Kawasaki T, Sumita Y, Egashira K, Ohba S, Kagami H, Tran SD, Asahina I: Transient Exposure to Hypoxic and Anoxic Oxygen Concentrations Promotes Either Osteogenic or Ligamentogenic Characteristics of PDL Cells. Biores Open Access 2015, 4(1):175-187.
118. Fang D, Hu S, Liu Y, Quan VH, Seuntjens J, Tran SD: Identification of the active components in Bone Marrow Soup: a mitigator against irradiation-injury to salivary glands. Sci Rep 2015, 5:16017.
119. Misuno K, Tran SD, Khalili S, Huang J, Liu Y, Hu S: Quantitative analysis of protein and gene expression in salivary glands of Sjogren's-like disease NOD mice treated by bone marrow soup. PLoS One 2014, 9(1):e87158.
120. Maria OM, Maria SM, Redman RS, Maria AM, Saad El-Din TA, Soussa EF, Tran SD: Effects of double ligation of Stensen's duct on the rabbit parotid gland. Biotech Histochem 2014, 89(3):181-198.
121. Khalili S, Faustman DL, Liu Y, Sumita Y, Blank D, Peterson A, Kodama S, Tran SD: Treatment for salivary gland hypofunction at both initial and advanced stages of Sj枚gren-like disease: a comparative study of bone marrow therapy versus spleen cell therapy with a 1-year monitoring period. Cytotherapy 2014, 16(3):412-423.
122. K芒 K, Rousseau MC, Tran SD, Kaartinen MT, Myneni VD, Henderson M, Nicolau B: Circulating undercarboxylated osteocalcin and gingival crevicular fluid tumour necrosis factor-伪 in children. J Clin Periodontol 2014, 41(5):467-472.
123. I T, Sumita Y, Minamizato T, Umebayashi M, Liu Y, Tran SD, Asahina I: Bone Marrow-derived Cell Therapy for Oral Mucosal Repair after Irradiation. J Dent Res 2014, 93(8):813-820.
124. Arellano-Garcia ME, Misuno K, Tran SD, Hu S: Interferon-纬 induces immunoproteasomes and the presentation of MHC I-associated peptides on human salivary gland cells. PLoS One 2014, 9(8):e102878.
125. Xia D, Sumita Y, Liu Y, Tai Y, Wang J, Uehara M, Agata H, Kagami H, Fan Z, Asahina I et al: GDFs promote tenogenic characteristics on human periodontal ligament-derived cells in culture at late passages. Growth Factors 2013, 31(5):165-173.
126. Tran SD, Liu Y, Xia D, Maria OM, Khalili S, Wang RW, Quan VH, Hu S, Seuntjens J: Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation. PLoS One 2013, 8(4):e61632.
127. Tamimi F, Comeau P, Le Nihouannen D, Zhang YL, Bassett DC, Khalili S, Gbureck U, Tran SD, Komarova S, Barralet JE: Perfluorodecalin and bone regeneration. Eur Cell Mater 2013, 25:22-36.
128. Nguyen TT, Mui B, Mehrabzadeh M, Chea Y, Chaudhry Z, Chaudhry K, Tran SD: Regeneration of tissues of the oral complex: current clinical trends and research advances. J Can Dent Assoc 2013, 79:d1.
129. Khosravi R, Ka K, Huang T, Khalili S, Nguyen BH, Nicolau B, Tran SD: Tumor necrosis factor- 伪 and interleukin-6: potential interorgan inflammatory mediators contributing to destructive periodontal disease in obesity or metabolic syndrome. Mediators Inflamm 2013, 2013:728987.
130. K芒 K, Rousseau MC, Lambert M, Tremblay A, Tran SD, Henderson M, Nicolau B: Metabolic syndrome and gingival inflammation in Caucasian children with a family history of obesity. J Clin Periodontol 2013, 40(11):986-993.
131. Durand R, Tran SD, Mui B, Voyer R: Managing postoperative pain following periodontal surgery. J Can Dent Assoc 2013, 79:d66.
132. Denis JF, L茅vesque M, Tran SD, Camarda AJ, Roy S: Axolotl as a Model to Study Scarless Wound Healing in Vertebrates: Role of the Transforming Growth Factor Beta Signaling Pathway. Adv Wound Care (New Rochelle) 2013, 2(5):250-260.
133. Maria OM, Maria AM, Cai Y, Tran SD: Cell surface markers CD44 and CD166 localized specific populations of salivary acinar cells. Oral Dis 2012, 18(2):162-168.
134. Khalili S, Liu Y, Kornete M, Roescher N, Kodama S, Peterson A, Piccirillo CA, Tran SD: Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sj枚gren's-like disease. PLoS One 2012, 7(6):e38615.
135. Alajbeg I, Falc茫o DP, Tran SD, Mart铆n-Granizo R, Lafaurie GI, Matranga D, Pejda S, Vuleti膰 L, Mantilla R, Leal SC et al: Intraoral electrostimulator for xerostomia relief: a long-term, multicenter, open-label, uncontrolled, clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol 2012, 113(6):773-781.
136. Tran SD, Sumita Y, Khalili S: Bone marrow-derived cells: A potential approach for the treatment of xerostomia. Int J Biochem Cell Biol 2011, 43(1):5-9.
137. Tran SD, Redman RS, Barrett AJ, Pavletic SZ, Key S, Liu Y, Carpenter A, Nguyen HM, Sumita Y, Baum BJ et al: Microchimerism in salivary glands after blood- and marrow-derived stem cell transplantation. Biol Blood Marrow Transplant 2011, 17(3):429-433.
138. Sumita Y, Liu Y, Khalili S, Maria OM, Xia D, Key S, Cotrim AP, Mezey E, Tran SD: Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation. Int J Biochem Cell Biol 2011, 43(1):80-87.
139. Strietzel FP, Lafaurie GI, Mendoza GR, Alajbeg I, Pejda S, Vuleti膰 L, Mantilla R, Falc茫o DP, Leal SC, Bezerra AC et al: Efficacy and safety of an intraoral electrostimulation device for xerostomia relief: a multicenter, randomized trial. Arthritis Rheum 2011, 63(1):180-190.
140. Maria OM, Zeitouni A, Gologan O, Tran SD: Matrigel improves functional properties of primary human salivary gland cells. Tissue Eng Part A 2011, 17(9-10):1229-1238.
141. Maria OM, Tran SD: Human mesenchymal stem cells cultured with salivary gland biopsies adopt an epithelial phenotype. Stem Cells Dev 2011, 20(6):959-967.
142. Maria OM, Maria O, Liu Y, Komarova SV, Tran SD: Matrigel improves functional properties of human submandibular salivary gland cell line. Int J Biochem Cell Biol 2011, 43(4):622-631.
143. Kuriki Y, Liu Y, Xia D, Gjerde EM, Khalili S, Mui B, Zheng C, Tran SD: Cannulation of the mouse submandibular salivary gland via the Wharton's duct. J Vis Exp 2011(51).
144. Khalili S, Liu Y, Sumita Y, Maria OM, Blank D, Key S, Mezey E, Tran SD: Bone marrow cells are a source of undifferentiated cells to prevent Sj枚gren's syndrome and to preserve salivary glands function in the non-obese diabetic mice. Int J Biochem Cell Biol 2010, 42(11):1893-1899.
145. Khosravi R, Tran SD, Lambert M, O'Loughlin J, K芒 K, Feine JS, Caron C, Tremblay A, Nicolau B: Adiposity and gingival crevicular fluid tumour necrosis factor-alpha levels in children. J Clin Periodontol 2009, 36(4):301-307.
146. Maria OM, Kim JW, Gerstenhaber JA, Baum BJ, Tran SD: Distribution of tight junction proteins in adult human salivary glands. J Histochem Cytochem 2008, 56(12):1093-1098.
147. Dai M, Li Y, Head TW, McKee MD, Tran SD, Dagenais M, Fromentin O, Lassauzay C, Nader SA, Albuquerque RF, Jr.: Point of care. J Can Dent Assoc 2008, 74(7):617-626.
148. Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Khalili S, Faustman DL, Mezey E: Reversal of Sjogren's-like syndrome in non-obese diabetic mice. Ann Rheum Dis 2007, 66(6):812-814.
149. Maria OM, Khosravi R, Mezey E, Tran SD: Cells from bone marrow that evolve into oral tissues and their clinical applications. Oral Dis 2007, 13(1):11-16.
150. Tran SD, Sugito T, Dipasquale G, Cotrim AP, Bandyopadhyay BC, Riddle K, Mooney D, Kok MR, Chiorini JA, Baum BJ: Re-engineering primary epithelial cells from rhesus monkey parotid glands for use in developing an artificial salivary gland. Tissue Eng 2006, 12(10):2939-2948.
151. Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E: Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. Science 2006, 314(5803):1243; author reply 1243.
152. Baum BJ, Tran SD: Synergy between genetic and tissue engineering: creating an artificial salivary gland. Periodontol 2000 2006, 41:218-223.
153. Tran SD, Wang J, Bandyopadhyay BC, Redman RS, Dutra A, Pak E, Swaim WD, Gerstenhaber JA, Bryant JM, Zheng C et al: Primary culture of polarized human salivary epithelial cells for use in developing an artificial salivary gland. Tissue Eng 2005, 11(1-2):172-181.
154. Kok MR, Voutetakis A, Yamano S, Wang J, Cotrim A, Katano H, Bossis I, Chiorini JA, Tran SD, Tak PP et al: Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors. J Gene Med 2005, 7(4):432-441.
155. Crain BJ, Tran SD, Mezey E: Transplanted human bone marrow cells generate new brain cells. J Neurol Sci 2005, 233(1-2):121-123.
156. Tran SD, Pillemer SR, Dutra A, Barrett AJ, Brownstein MJ, Key S, Pak E, Leakan RA, Kingman A, Yamada KM et al: Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet 2003, 361(9363):1084-1088.
157. Tran H, Pankov R, Tran SD, Hampton B, Burgess WH, Yamada KM: Integrin clustering induces kinectin accumulation. J Cell Sci 2002, 115(Pt 10):2031-2040.
158. Baum BJ, Kok M, Tran SD, Yamano S: The impact of gene therapy on dentistry: a revisiting after six years. J Am Dent Assoc 2002, 133(1):35-44.
159. Aframian DJ, Tran SD, Cukierman E, Yamada KM, Baum BJ: Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland. Tissue Eng 2002, 8(5):871-878.
160. Tran SD, Rudney JD, Sparks BS, Hodges JS: Persistent presence of Bacteroides forsythus as a risk factor for attachment loss in a population with low prevalence and severity of adult periodontitis. J Periodontol 2001, 72(1):1-10.
161. Tran SD, Rudney JD: Improved multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Porphyromonas gingivalis. J Clin Microbiol 1999, 37(11):3504-3508.
162. Tran SD, Rudney JD: Multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. J Clin Microbiol 1996, 34(11):2674-2678.
163. Alpagot T, Wolff LF, Smith QT, Tran SD: Risk indicators for periodontal disease in a racially diverse urban population. J Clin Periodontol 1996, 23(11):982-988.
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