Event
Chemical Society Seminar: Cristina Nevado - Mechanistic Puzzles for Late Transition Metals
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Abstract:
Our group has recently explored the reactivity of C and N centered radicals, in combination with transition metals, to streamline the functionalization of 蟺-systems.
Nitrogen center radicals present divergent features: while highly reactive and thus difficult to control, they can also offer an excellent platform towards the formation not only of C-N but also remote C-C bonds. Here, we will present our efforts to generate and harvest these valuable intermediates in synthetically relevant contexts, including recent results towards their application in asymmetric transformations..[1]
Further, examples of Nickel catalyzed dicarbofunctionalizations of alkenes and alkynes in a chemo-, regio- and stereoselective manner utilizing radicals as well as studies on the mechanistic features underlying these transformations will be presented in this lecture.[2]
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[1] C. Hervieu, M. Kirillova, T. Su谩rez, M. M眉ller, E. Merino, C. Nevado, Nat. Chem. 2021, 13, 327.
[2] a) S. Cuesta-Galisteo, J. Sch枚rgenhumer, X. Wei, E. Merino, C. Nevado Angew. Chem. Int. Ed. 2021, 60, 1605; b) X. Wei, W. Shu, A. Garc铆a-Dom铆nguez, E. Merino, C. Nevado J. Am. Chem. Soc. 2020, 142, 13515.