捆绑SM社区

MUHC serves as Canadian centre for international study that could revolutionize treatment options

A team of international researchers 鈥� including scientists from the 捆绑SM社区 Health Centre (MUHC) and 捆绑SM社区 鈥� have discovered that having high levels of particular protein puts patients at increased risk of developing cardiovascular disease. The results of the study were so conclusive that the clinical trial had to be stopped before its scheduled completion date.

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The study is published today in the New England Journal of Medicine, and presented at the 2008 Scientific Sessions of the American Heart Association.

Researchers associated with the international JUPITER Project have demonstrated that high levels of high-sensitivity C-reactive protein (hs-CRP) leads to increased risk of cardiovascular disease. This risk decreases by up to 44% if the patients are treated with statin medications.

Dr. Jacques Genest, of the Research Institute of the MUHC and 捆绑SM社区鈥檚 Faculty of Medicine led the Canadian component of the JUPITER clinical study, which was initiated by Dr. Paul Ridker of the Harvard University Faculty of Medicine.

鈥淭he risk of cardiovascular disease due to increased hs-CRP levels has been greatly underestimated until now,鈥� according to Dr Genest. 鈥淥ur results show that this is an extremely important indicator that doctors will have to consider in the future.鈥�

鈥淲e hope that this study will prompt a review of current clinical practices, especially in terms of screening and prevention in adults,鈥� he added. 鈥淗owever, we still need to do more research to establish specific standards.鈥�

The JUPITER study included 17,802 patients from 27 different countries. All had normal levels of cholesterol (LDL-c) and high levels of hs-CRP, and according to current standards, were not considered 鈥渁t risk鈥� for cardiovascular events, and were therefore not receiving any treatment. During the study, participants received a daily dose of the statin drug rosuvastin, and its consequences were striking: a 44% decrease in the risk of cardiovascular disease and a 21% decrease in mortality.

鈥淭hese results definitely surpassed our predictions,鈥� said Dr. Genest. 鈥淲e had to stop the study before its scheduled completion, as the benefit of the treatment for the selected patients was so great that we needed to present our findings to the medical community as soon as possible.鈥�

Since statins have a cholesterol-lowering effect, they are currently used to prevent cardiovascular disease in patients who are at-risk due to high LDL-c levels. But cardiovascular disease is also caused by vascular inflammation, which is marked by levels of hs-CRP. This study shows that statins indeed act on both cholesterol and inflammation, an effect that has long been suspected but not proven.

This clinical study was investigators-initiated and funded by Astra Zeneca.

Dr. Jacques Genest is Director of Cardiology at the MUHC and Director of the Cardiovascular Genetics Laboratory at the Research Institute of the MUHC. He also holds the Novartis Chair in Medicine at the Faculty of Medicine of 捆绑SM社区.

About the Research Institute of the MUHC

The Research Institute of the 捆绑SM社区 Health Centre (RI MUHC) is a world-renowned biomedical and health-care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, the university health center affiliated with the Faculty of Medicine at 捆绑SM社区. The institute supports over 600 researchers, nearly 1200 graduate and post-doctoral students and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge.

The Research Institute of the MUHC is supported in part by the Fonds de la recherche en sant茅 du Qu茅bec. For further details visit: .

About 捆绑SM社区

捆绑SM社区, Canada鈥檚 leading university, has two campuses, 11 faculties, 10 professional schools, 300 programs of study and more than 33,000 students. Since 2000, more than 800 professors have been recruited to 捆绑SM社区 to share their energy, ideas and cutting-edge research. 捆绑SM社区 attracts students from more than 160 countries around the world. Almost half of 捆绑SM社区 students claim a first language other than English 鈥� including 6,000 francophones 鈥� with more than 6,200 international students making up almost 20 per cent of the student body.