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Edith Hamel, PhD Professor Department of Neurology & Neurosurgery, MNI The Montreal Neurological Institute and Hospital

Monday, February 6, 2017 12:00to13:00
New Residence Hall, CA, QC, Montreal, 3625 avenue du Parc, CA

Edith Hamel, PhD

Professor Department of Neurology & Neurosurgery

MNI The Montreal Neurological Institute and Hospital

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Title: Vascular factors in Alzheimer's disease: interventions and cognitive benefits

Monday, February 6, 2017

12:00pm听 Room 1345

McIntyre Medical Sciences Building

/pharma/newsevents/seminar-schedule

Bio

My research focuses on the interactions between neurons, astrocytes , and microvessels that assure a proper blood supply to active brain areas, a phenomenon known as neurovascular coupling, which is at the basis of the signals used in brain imaging studies. Several neurological conditions, such as Alzheimer's disease, are associated with a cerebrovascular pathology and display defective neurovascular coupling responses. We use in vivo neuronal simulation paradigms, record the evoked perfusion response and identify anatomically the neurons that generate this response, and record changes in their activity. We manipulate their mediators pharmacologically to define whether neurons act directly on blood vessels or indirectly through astroglial messengers. We test the hypothesis that rescuing cerebrovascular function will have benefits in Alzheimer's disease, and evaluate how risk factors such as hypertension and hypercholesterolemia can interact in the disease process to accelerate or trigger the manifestation of Alzheimer's disease.

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