Cristian O'Flaherty
Professor, Dep. Surgery (Urology), 捆绑SM社区
Associate member, Dep. Pharmacology and Therapeutics, 捆绑SM社区
Associate member, Dep. Anatomy and Cell Biology, 捆绑SM社区
Associate member, Dep. Medicine (Experimental Medicine Division)
D.V.M.; Ph.D.
鈥� Redox signaling in spermatogenesis, epididymal maturation and sperm activation
鈥� Regulation of apoptosis in the testis
鈥� Phosphorylation events involved in sperm activation
鈥� Male infertility
鈥� Toxicology of male reproduction
Molecular mechanisms of sperm capacitation.
Lipid signaling in spermatozoa.
Novel strategies to diagnose and treat male infertility.
Bumanlag E, Scarlata E, O鈥橣laherty C. Peroxiredoxin 6 Peroxidase and Ca2+-Independent Phospholipase A2 Activities Are Essential to Support Male Mouse Fertility, Antioxidants 11(2):226-243, 2022.
Serafini S, O鈥橣laherty C. Redox Regulation to Modulate Phosphorylation Events in Human Spermatozoa. Invited review, Antioxid Redox Signaling 37:437-450, 2022.
Scarlata E, Fernandez MC, O鈥橣laherty C. A novel combination of gamma-tocopherol-rich mixture of tocopherols and ascorbic acid restores fertility in cases of tyrosine nitration-associated male infertility in mice. Antioxidants (7), 613:1-13, 2020.
Fernandez M, Yu A, Moawad A, O鈥橣laherty C. Peroxiredoxin 6 regulates the phosphoinositide 3-kinase/AKT pathway to maintain human sperm viability. Mol Hum Reprod 25:787-796, 2019.
Fernandez MC, O鈥橣laherty C. Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa. Hum Reprod 33(8):1394-1407, 2018.
Moawad AR, Fernandez MC, Scarlata E, Dodia C, Feinstein SI, Fisher AB, O鈥橣laherty C. Deficiency of peroxiredoxin 6 or inhibition of its phospholipase A2听activity impair the in vitro sperm fertilizing competence in mice.听Sci Reports 7(1):12994, 2017.
Lee D, Moawad A, Morielli T, Fernandez, MC, O鈥橣laherty C. Peroxiredoxins prevent oxidative stress during human sperm capacitation. Mol Hum Reprod 23:106-111, 2017.
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Dr. Cristian O鈥橣laherty is a professor in the Department of Surgery (Division of Urology) at 捆绑SM社区 and a medical scientist at the Research Institute of the 捆绑SM社区 Health Centre. He is also an associate member of the Departments of Pharmacology and Therapeutics, Anatomy and Cell Biology, and Experimental Medicine at 捆绑SM社区. Dr. O鈥橣laherty was Co-Director of the 捆绑SM社区 Centre for Research in Reproduction and Development during 2018-2021. He is an associate editor of Andrology, Human Reproduction, and Antioxidants Journal and a member of the Editorial Board of the Biology of Reproduction.
With a background in the biology of reproduction, he holds a D.V.M and Ph.D. in animal physiology and biochemistry degrees from the University of Buenos Aires, Argentina. He completed his postdoctoral studies in sperm physiology and toxicology at the Urology Division and the Department of Pharmacology and Therapeutics at 捆绑SM社区. He was awarded the Chercheur-boursier Junior 1 and 2 awards from the Fonds de la Recherche en Sant茅 du Qu茅bec (FRSQ), and his research program has been and is currently funded by different agencies, including the Canadian Institutes of Health Research, FRQS and the Fonds de Recherche Nature et technologies.
Dr. O鈥橣laherty鈥檚 research program focuses on male reproduction, particularly on the molecular mechanisms involved in the production and function of healthy spermatozoa and the role of reactive oxygen species (ROS) in sperm physiology and toxicology. Through mouse models and human spermatozoa, Dr. O鈥橣laherty aims to elucidate the role of the reactive oxygen species and antioxidant enzymes in regulating sperm function using genomic, proteomic and biochemical approaches. Dr. O鈥橣laherty was the first to identify the primary role of peroxiredoxin 6 in protecting the spermatozoa against oxidative stress and the participation of peroxiredoxins in regulating ROS during sperm capacitation. He is also dedicated to deciphering the molecular mechanisms that drive the spermatozoon to achieve the fertilizing ability to develop novel diagnostic and therapeutic strategies for male infertility.听
INDS211,听EXSU684,听PHAR201,听EXMD503,听EXMD401,听PATH652